QREM Cytokine – Autologous Cytokine-Rich Serum 

QREM Cytokine Autologous Cytokine-Rich Serum: Treatment of osteoarthritis of the knee

How does the regenerative cycle take place?

SARC directly contains cytokines that promote the correct completion of the regenerative cycle, preventing the inflammatory and proliferative phases from becoming prolonged and even chronic.

Phases in the recovery of an injury:

• Hemostasis: platelets are activated and release pro-inflammatory cytokines that call white blood cells to begin the process of tissue regeneration.
• Inflammation: white blood cells clean the injured area and release other cytokines that recruit cells to replace the damaged cells.
• Proliferation: blood vessels are created to feed the new cells that accumulate around the injured tissue.
• Remodeling: other cytokines stop the accumulation of new cells and these cells are organized giving rise to healthy tissue.

Cytokines and the inflammatory process in osteoarthritis

Our body controls inflammatory processes through special messengers (proteins).

These messengers couple to the corresponding signaling points of the tissue cells and transmit their message: “trigger inflammation” or “stop inflammation”.

In case of osteoarthritis, the balance of anti-inflammatory and pro-inflammatory messengers is disturbed in the affected joint.

Due to an imbalance of proteins in the body, harmful interleukin-1 (IL-1) causes cartilage damage, inflammation and pain.

The natural interleukin-1 antagonist is the interleukin-1 receptor antagonist (IL-1Ra), which is called“osteoarthritis inhibitory protein“.

Osteoarthritis inhibitory protein (IL-1Ra) occupies specific synapses – or cell signaling sites – on cartilage cells and synovial membrane cells, thereby preventing access of the harmful IL-1 protein to these cellular areas.

QREM Cytokine autologous serum treatment

What is Qrem cytokine?

Qrem Cytokine technology is a system that allows us to obtain autologous serum rich in cytokines (SARC) from a patient’s blood collection.

Cytokines are involved in the regeneration processes of tissues with degenerative problems and are used for the treatment of musculoskeletal pathologies.

Autologous serum enriched in cytokines is demonstrating greater efficacy than current platelet and growth factor therapies.

This kit is a medical device marketed in Spain with CE marking.

It is a Lab-in-a-Box device, a closed, automatic bench-top system, consisting of a device (Q-Device) and a single-use disposable sterile kit (Q-kit).

What are the advantages of Qrem cytokine technology?

• Drug-free procedure: since it does not contain any drugs, the serum does not have the side effects of current treatments.
• Natural activation: SARC’s mechanism of action promotes the reduction of joint inflammation and activates cartilage repair through the patient’s own cytokines .
• There is no risk of rejection and it can be administered as many times as necessary.
• It contains cytokines, proteins released by cells and other activators of the regeneration system such as platelet growth factors, showing superior results to other biological therapies.
• Lab-in-a-Box technology, fast and safe: the serum is obtained with the Qrem Cytokine device incorporating advanced Lab-in-a-box technology.
• Qrem regenerative technology guarantees sterility and allows its use in medical centers. It can be obtained quickly, avoiding the risks that can be involved in the preservation of biological products.

Qrem Cytokine Regenerative Technology Applications

By effectively controlling the inflammatory cascade, Citokine QREM Serum can be used to effectively treat inflammatory conditions in the following medical areas:

• Orthopedics and sports medicine.
• Physical rehabilitation and pain management.

In our clinic we use autologous serum always under medical prescription, for the treatment of pathologies such as ankle osteoarthritis, knee osteoarthritis, chondromalacia patella or meniscopathies and meniscus tears.